Current Status and Future of Artificial Blood - Focusing on Red Blood Cell Substitutes
نویسندگان
چکیده
منابع مشابه
Red blood cell substitutes: current status.
The transfusion of allogeneic blood (or plasma or red cells) involves many hoards (see table 1), some of which may be reduced or avoided. For example, the patient's own blood rather than allogeneic blood may be transfused: by 1990 more than 5% of units collected in the USA were of autologous blood [42]. In the United Kingdom, the National Transfusion Service is now, in some regions at least, pr...
متن کاملFuture generations of red blood cell substitutes.
Polyhaemoglobins (PolyHb) and perfluorochemicals are in advanced phase III clinical trials and conjugated haemoglobins in phase II clinical trial. New recombinant human haemoglobin with no vasoactivity is being developed. A soluble macromolecule of PolyHb-catalase-superoxide dismutase is being studied as an oxygen carrier with antioxidant properties. New artificial red blood cells that are more...
متن کاملArtificial oxygen carriers as red blood cell substitutes: a selected review and current status.
Two distinct approaches are being explored in red blood cell substitute (RCS) development: hemoglobin-based oxygen carriers (HBOCs) and perfluorocarbon-based oxygen carriers (PFBOCs). HBOCs are based on intra- and/or intermolecularly "engineered" human or animal hemoglobins (Hbs), optimized for O2 delivery and longer intravascular circulation. Some are currently being evaluated in Phase II/III ...
متن کاملArtificial blood: an update on current red cell and platelet substitutes.
Interestingly, artificial blood an update on current red cell and platelet substitutes that you really wait for now is coming. It's significant to wait for the representative and beneficial books to read. Every book that is provided in better way and utterance will be expected by many peoples. Even you are a good reader or not, feeling to read this book will always appear when you find it. But,...
متن کاملHemoglobin-based red blood cell substitutes.
Polyhemoglobin is already well into the final stages of clinical trials in humans with one approved for routine clinical use in South Africa. Conjugated hemoglobin is also in ongoing clinical trials. Meanwhile, recombinant Hb has been modified to modulate the effects of nitric oxide. Other systems contain antioxidant enzymes for those clinical applications that may have potential problems relat...
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ژورنال
عنوان ژورنال: Journal of the Korean Medical Association
سال: 2009
ISSN: 1975-8456
DOI: 10.5124/jkma.2009.52.2.168